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Documented mechanisms relevant to skin ageing include: COL1A1 and COL3A1 transcriptional upregulation in dermal fibroblasts (multiple independent groups) MMP-2 and MMP-9 regulation (balanced remodelling rather than pure degradation) TIMP-1/TIMP-2 upregulation maintaining MMP-TIMP homeostasis Hyaluronan synthase (HAS1/HAS2) upregulation improving dermal hydration biology Fibronectin and decorin production for ECM structural integrity Epidermal keratinocyte migration and proliferation (scratch assay, organotypic skin model data) Epitalon’s dermal relevance is primarily indirect — via melatonin restoration (melatonin has photoprotective and anti-photoageing activity in skin) and systemic antioxidant effects rather than direct fibroblast or keratinocyte biology